A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Kavitha, A. N.
- Application of Design of Experiments for Optimizing Critical Quality Attributes (CQA) in Routine Pharmaceutical Product Development
Authors
1 Department of Quality Assurance, Krupanidhi College of Pharmacy, Chikkabellandur Village, Carmelaram Post, Varthur Hobli, Bangalore - 560035, IN
2 Department of Pharmaceutics, Krupanidhi College of Pharmacy, Chikkabellandur Village, Carmelaram Post, Varthur Hobli, Bangalore - 560035, IN
Source
Journal of Pharmaceutical Research, Vol 15, No 3 (2016), Pagination: 96-100Abstract
Purpose: QbD is a helpful tool in building quality products and to understand critical process parameters which affects the manufacturing of drug products. It helps to build control strategy which helps to maintain quality throughout its life cycle.
Approaches: The major approach in QbD is through DOE which includes either screening or optimization done by various designs like plackett-Burmann, Box-Behnken design, Fractional Factorial design, Central Composite design, Mixture design etc.
Findings: QbD approach helps in formulating and maintaining quality in the drug product. It helps to identify the critical quality attributes and process parameters which are likely to affect the quality of the drug product through screening design.
Conclusions: Adopting QbD concepts into manufacturing of the drug product has its advantage of reducing development and marketing costs. It also helps in meeting regulatory requirements.
Keywords
QbD, DOE, Process Optimization, QTPP, CQA.References
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- Comparative In Vitro Antimicrobial Activity of Three Different Macro Fungus Extracts against Clinical Isolates of Gram-Negative Pathogens
Authors
1 Department of Pharmaceutics, Krupanidhi College of Pharmacy, Chickabellandur, Varthur Hobli, Bangalore-560035, IN
2 Department of Pharmaceutical Chemistry, Krupanidhi College of Pharmacy, Bangalore, IN
3 Department of Pharmaceutics, Krupanidhi College of Pharmacy, Bangalore, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 4, No 1 (2012), Pagination: 29-32Abstract
The three species of edible mushrooms fistulina hepatica, cantharellus cibarius, lepistanuda were collected from the Western Ghats and malnad forest area of Karnataka. Methanolic extracts of these three edible mushrooms were used in this study. Among the isolated mushrooms fistulina hepatica and cantharellus cibarius were showed satisfactory results. Determination of antimicrobial activity profile of all the isolates tested against a panel of standard pathogenic bacteria indicated that the concentrations of bioactive components directly influence the antimicrobial capability of the isolates. Agar diffusion assay showed considerable activity against all bacteria. These results are discussed in relation to therapeutic value of the studied mushrooms using the cup plate and paper disc methods. Gram negative microorganisms studied were Escherichia coli, Solmonella typhi, Morexella, H.influenza. Neisseria gonorrhoeae.
For examination of pathogenic microorganisms in the cup plate and disc diffusion method, methanolic extracts of concentrations of 250 and 500 micrograms per cup and disc were used. All the three extracts have demonstrated significant antimicrobial activities in both methods.